缺血性心肌病與能量代謝研究進展

創建日期:  2019/07/04  王婧   瀏覽次數:   返回

《上海大學學報(自然科學版)》2019年25卷3期:357-364

缺血性心肌病與能量代謝研究進展
張劍姝, 徐明
北京大學第三醫院 心血管內科, 血管醫學研究所, 國家衛生健康委心血管分子生物學與調節肽重點實驗室, 分子心血管學教育部重點實驗室, 心血管受體研究北京市重點實驗室, 北京 100191
摘要 缺血性心肌病伴隨著心臟能量代謝的變化,這些變化主要為脂肪酸氧化速率增加和/或葡萄糖氧化途徑中糖酵解減少.通過減少脂肪酸氧化或者增加葡萄糖氧化的方式干預能量代謝,能夠改善缺血性心肌病的病理變化和心臟功能.隨著代謝組學檢測技術的發展,針對缺血性心肌病進行早期代謝產物檢測手段和機制探索方式更加多樣,豐富了目前對缺血性心肌病代謝變化的認知.同時,了解并分析缺血性心肌病的代謝變化能為缺血性心肌病的創新藥物研發提供新線索.系統介紹了缺血性心肌病中三大營養物質能量代謝變化,干預不同能量變化在心臟功能障礙中的作用,并探討通過代謝手段治療缺血性心臟疾病的可能性.
關鍵詞:  缺血性心肌病  脂肪酸氧化  代謝   

Research progress on ischemic heart disease and energy metabolism
ZHANG Jianshu, XU Ming

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China

Abstract: Ischemia heart disease is often accompanied by cardiac energy metabolism, which is reflected in contractile dysfunction and a decrease in cardiac efficiency. Specific metabolic changes include a relative increase in cardiac fatty acid oxidation rates and an uncoupling of glycolysis from glucose oxidation. Recent evidence suggests that therapeutically regulating cardiac energy metabolism by reducing fatty acid oxidation and/or increasing glucose oxidation can improve cardiac function of the ischemic heart. With the development of metabolomics technology, the detection methods and mechanisms of early metabolites for ischemic cardiomyopathy are further explored. This paper first discusses systematically the change of energy metabolic which contributes to cardiac dysfunction, and then it explores the potential for targeting treatment ischemic heart disease through metabolic pathway.
Key words:  ischemia heart disease    fatty acid oxidation    metabolism
全文鏈接:http://www.journal.shu.edu.cn/fileup/1007-2861/PDF/20190301.pdf



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